Mutations in the SLC30A8 gene are not a major cause of MODY or other forms of early-onset, autosomal dominant type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Mutations in MODY genes are not common cause of early-onset type 2 diabetes in Mexican families.
CONTEXT Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized by autosomal dominant inheritance, early age of onset and a primary insulin secretion defect. Certain MODY gene sequence variants may be involved in polygenic forms of type 2 diabetes. OBJECTIVE We assessed the contribution of MODY genes to the etiology of type 2 early-onset diabetes in ...
متن کاملAs a Major Locus for Early-Onset Autosomal Dominant Type 2 Diabetes
We investigated whether variability at the insulin receptor substrate (IRS)-2 locus plays a role in the etiology of early-onset autosomal dominant type 2 diabetes. By means of radiation hybrid mapping, we placed the human IRS-2 gene on 13q at 8.6 cRays from SHGC37358. Linkage between diabetes and two polymorphic markers located in this region (D13S285 and D13S1295) was then evaluated in 29 fami...
متن کاملGCK gene mutations are a common cause of childhood‐onset MODY (maturity‐onset diabetes of the young) in Turkey
OBJECTIVE Inactivating heterozygous mutations in the GCK gene are a common cause of MODY and result in mild fasting hyperglycaemia, which does not require treatment. We aimed to identify the frequency, clinical and molecular features of GCK mutations in a Turkish paediatric cohort. DESIGN AND PATIENTS Fifty-four unrelated probands were selected based on the following criteria: age of diagnosi...
متن کاملNon-ketotic diabetes in Saudi Arabian youths: MODY or early onset of type 2 diabetes?
Background: Non-ketotic diabetes mellitus is commonly seen in young Saudi Arabian adults. This could be either early onset of typical type 2 diabetes, T2DM or maturity-onset diabetes of the young, MODY. Consanguinity is also prevalent and clouds the inheritance pattern of the disease. Distinction between the two on clinical grounds alone is not always possible. Materials and Method: Diabetic pa...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2007
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-007-0777-y